482 research outputs found
Recovering a spinning inspiralling compact binary waveform immersed in LIGO-like noise with spinning templates
We investigate the recovery chances of highly spinning waveforms immersed in
LIGO S5-like noise by performing a matched filtering with 10^6 randomly chosen
spinning waveforms generated with the LAL package. While the masses of the
compact binary are reasonably well recovered (slightly overestimated), the same
does not hold true for the spins. We show the best fit matches both in the
time-domain and the frequency-domain. These encompass some of the spinning
characteristics of the signal, but far less than what would be required to
identify the astrophysical parameters of the system. An improvement of the
matching method is necessary, though may be difficult due to the noisy signal.Comment: 5 pages, 1 figure + 4 figure panels; Proceedings of the Eight Edoardo
Amaldi Conference on Gravitational Waves (Amaldi8), New York, 2009; to be
published in J. Phys.: Conf. Series (JPCS
Results of Aortocoronary Bypass Surgery for Angina Pectoris
To determine the relative risks and benefits of coronary bypass surgery for angina pectoris, we examined the results in our first consecutive 360 patients operated upon between May 1970 and December 1975. The age range was 27 to 75 years; there were 309 males and 51 females. The patients were classified clinically as having stable angina in 119 cases (33%), unstable angina in 205 cases (57%) and preinfarction angina in 36 cases (10%). Unstable angina was defined as a definite recent increase in severity or frequency of chest pain, angina at rest or nocturnal angina. Preinfarction angina was defined as a syndrome of prolonged angina, poorly controlled by nitrites, occurring at rest with typical ECG changes of ischemia. Such patients underwent observation in the Coronary Intensive Care Unit followed by emergency arteriography and surgery, usually within 24 hours
An integrated gene regulatory network controls stem cell proliferation in teeth.
Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation, and are responsible for the continuous regeneration of tissues such as hair, skin, and gut. Although the regenerative potential of mammalian teeth is limited, mouse incisors grow continuously throughout life and contain stem cells at their proximal ends in the cervical loops. In the labial cervical loop, the epithelial stem cells proliferate and migrate along the labial surface, differentiating into enamel-forming ameloblasts. In contrast, the lingual cervical loop contains fewer proliferating stem cells, and the lingual incisor surface lacks ameloblasts and enamel. Here we have used a combination of mouse mutant analyses, organ culture experiments, and expression studies to identify the key signaling molecules that regulate stem cell proliferation in the rodent incisor stem cell niche, and to elucidate their role in the generation of the intrinsic asymmetry of the incisors. We show that epithelial stem cell proliferation in the cervical loops is controlled by an integrated gene regulatory network consisting of Activin, bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and Follistatin within the incisor stem cell niche. Mesenchymal FGF3 stimulates epithelial stem cell proliferation, and BMP4 represses Fgf3 expression. In turn, Activin, which is strongly expressed in labial mesenchyme, inhibits the repressive effect of BMP4 and restricts Fgf3 expression to labial dental mesenchyme, resulting in increased stem cell proliferation and a large, labial stem cell niche. Follistatin limits the number of lingual stem cells, further contributing to the characteristic asymmetry of mouse incisors, and on the basis of our findings, we suggest a model in which Follistatin antagonizes the activity of Activin. These results show how the spatially restricted and balanced effects of specific components of a signaling network can regulate stem cell proliferation in the niche and account for asymmetric organogenesis. Subtle variations in this or related regulatory networks may explain the different regenerative capacities of various organs and animal species
Recommended from our members
Kinematic Responses to Changes in Walking Orientation and Gravitational Load in Drosophila melanogaster
Walking behavior is context-dependent, resulting from the integration of internal and external influences by specialized motor and pre-motor centers. Neuronal programs must be sufficiently flexible to the locomotive challenges inherent in different environments. Although insect studies have contributed substantially to the identification of the components and rules that determine locomotion, we still lack an understanding of how multi-jointed walking insects respond to changes in walking orientation and direction and strength of the gravitational force. In order to answer these questions we measured with high temporal and spatial resolution the kinematic properties of untethered Drosophila during inverted and vertical walking. In addition, we also examined the kinematic responses to increases in gravitational load. We find that animals are capable of shifting their step, spatial and inter-leg parameters in order to cope with more challenging walking conditions. For example, flies walking in an inverted orientation decreased the duration of their swing phase leading to increased contact with the substrate and, as a result, greater stability. We also find that when flies carry additional weight, thereby increasing their gravitational load, some changes in step parameters vary over time, providing evidence for adaptation. However, above a threshold that is between 1 and 2 times their body weight flies display locomotion parameters that suggest they are no longer capable of walking in a coordinated manner. Finally, we find that functional chordotonal organs are required for flies to cope with additional weight, as animals deficient in these proprioceptors display increased sensitivity to load bearing as well as other locomotive defects
Chemical Abundances in Field Red Giants from High-Resolution H-Band Spectra using the APOGEE Spectral Linelist
High-resolution H-band spectra of five bright field K, M, and MS giants,
obtained from the archives of the Kitt Peak National Observatory (KPNO) Fourier
Transform Spectrometer (FTS), are analyzed to determine chemical abundances of
16 elements. The abundances were derived via spectrum synthesis using the
detailed linelist prepared for the SDSS III Apache Point Galactic Evolution
Experiment (APOGEE), which is a high-resolution near-infrared spectroscopic
survey to derive detailed chemical abundance distributions and precise radial
velocities for 100,000 red giants sampling all Galactic stellar populations.
Measured chemical abundances include the cosmochemically important isotopes
12C, 13C, 14N, and 16O, along with Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, Co,
Ni, and Cu. A comparison of the abundances derived here with published values
for these stars reveals consistent results to ~0.1 dex. The APOGEE spectral
region and linelist is, thus, well-suited for probing both Galactic chemical
evolution, as well as internal nucleosynthesis and mixing in populations of red
giants using high-resolution spectroscopy.Comment: Accepted for publication in The Astrophysical Journal. 42 pages, 12
figure
12C/13C isotopic ratios in red-giant stars of the open cluster NGC 6791
Carbon isotope ratios, along with carbon and nitrogen abundances, are derived
in a sample of 11 red-giant members of one of the most metal-rich clusters in
the Milky Way, NGC 6791. The selected red-giants have a mean metallicity and
standard deviation of [Fe/H]=+0.39+-0.06 (Cunha et al. 2015). We used high
resolution H-band spectra obtained by the SDSS-IV Apache Point Observatory
Galactic Evolution Experiment (APOGEE). The advantage of using high-resolution
spectra in the H-band is that lines of CO are well represented and their line
profiles are sensitive to the variation of 12C/13C. Values of the 12C/13C ratio
were obtained from a spectrum synthesis analysis. The derived 12C/13C ratios
varied between 6.3 and 10.6 in NGC 6791, in agreement with the final isotopic
ratios from thermohaline-induced mixing models. The ratios derived here are
combined with those obtained for more metal poor red-giants from the literature
to examine the correlation between 12C/13C, mass, metallicity and evolutionary
status.Comment: Accepted for publication in MNRAS, 9 pages, 4 figures, 2 table
The equational theories of representable residuated semigroups
We show that the equational theory of representable lower semilattice-ordered residuated semigroups is finitely based. We survey related results
- âŠ